Abstract: Aldehyde dehydrogenase proteins consist of a superfamily and the family 7 ( ALDH7 ) is a typical group with highly conserved proteins across species .
It catalyzes oxidation of alpha-aminoadipic semialdehyde ( AASA ) in lysine degradation , participates in protection against hyperosmotic stress , and detoxifies aldehydes in human ; however , its function in plants has been much less documented .
Here we reported a mutant with yellow-colored endosperm in rice , and showed that the yellow endosperm was caused by mutation of OsALDH7 .
OsALDH7 is expressed in all it issues detected , with the highest level in mature seeds .
We found that oryzamutaic acid A accumulated during late seed development and after a year-long storage in the colored endosperm , whereas it was undetectable in the wild type endosperm .
Moreover , lysine degradation was enhanced in yeast over-expressing OsALDH7 and as a result , content of lysine , glutamate and saccharopine was changed , suggesting a role of OsALDH7 in lysine catabolism .
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